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Will collaborate to develop XmAb5871.

Miletich, M.D., Ph.D., senior vice president, Analysis & Advancement at Amgen. We are delighted to have the opportunity to partner with Xencor in exploring their novel immunomodulatory strategy. Amgen’s long-time leadership in antibody advancement for oncology and inflammatory illnesses aligns seamlessly with Xencor’s pipeline advancement, said Bassil Dahiyat, Ph.D., chief executive officer of Xencor. We anticipate that XmAb5871 will soon become the fifth XmAb-engineered antibody in medical development. This program is definitely a testament to the progress we’ve made growing the XmAb system into autoimmune disease with our CD32b technology, which is at the core of the XmAb5871 substance. The choice deal structure allows us to continue steadily to lead the advancement of XmAb5871 while also leveraging Amgen’s experience in developing novel biologics for unmet medical demands.This 'immune hypothesis' is backed by new work colleagues in the current issue of Biological Psychiatry Researchers from the youngsters Study Institute at the Kids's Medical center, Westmead, and the University of Sydney detected antibodies to the dopamine D2 receptor or the N-methyl-D-aspartate glutamate receptor among eight out of 43 kids experiencing their first episode of psychosis, but no such antibodies in healthy children. Both are fundamental neural signaling proteins been implicated in psychosis previously. ‘The antibodies we have detected in kids having a first episode of acute psychosis suggest there is a unique subgroup for whom autoimmunity plays a role in their illness,’ says the University of Sydney's Dr Fabienne Brilot, the senior writer on the paper and Head of the Neuroimmunology Group at The Kids's Hospital at Westmead in Sydney.

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